منابع مشابه
Ontogenetic Variation of the Human Genome
The human genome demonstrates variable levels of instability during ontogeny. Achieving the highest rate during early prenatal development, it decreases significantly throughout following ontogenetic stages. A failure to decrease or a spontaneous increase of genomic instability can promote infertility, pregnancy losses, chromosomal and genomic diseases, cancer, immunodeficiency, or brain diseas...
متن کاملOntOgenetic and Sexual VariatiOn
Aegialomys xanthaeolus (Cricetidae: Sigmodontinae) inhabits the arid montane areas of western Ecuador and Peru, and higher elevations in the upper Marañón valley in northern Peru. Some researchers have included this species in broader systematic assessments over the years, but there are no comprehensive studies focusing on intraspecific variation. There are several sources of intraspecific phen...
متن کاملStructural variation of the human genome.
There is growing appreciation that the human genome contains significant numbers of structural rearrangements, such as insertions, deletions, inversions, and large tandem repeats. Recent studies have defined approximately 5% of the human genome as structurally variant in the normal population, involving more than 800 independent genes. We present a detailed review of the various structural rear...
متن کاملHuman Genome Sequence and Variation
The knowledge of the content of the individual human genomes has become a sine qua non for the understanding of the relationship between genotypic and phenotypic variability. The genome sequence and the ongoing functional annotation require both comparative genome analysis among different species and experimental validation. Extensive common and rare genomic variability exists that strongly inf...
متن کاملStructural variation in the human genome.
Genomic structural variation is generally defined as deletions, insertions, duplications, inversions, translocations or copy number variation (CNV) in large DNA segments (>1 kb). The structural variation in an individual genome includes thousands of discrete regions, spans millions of base pairs, and encompasses numerous entire genes and their regulatory regions. This results in missing or chan...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2010
ISSN: 1389-2029
DOI: 10.2174/138920210793175958